Physics Colloquium: 10 Hard Puzzles of the Soft Airway Surface Layer

Prof. Michael Rubinstein, Ph.D., Mechanical Engineering and Materials Science, Biomedical Engineering, Physics, & Chemistry Department, Duke University, Marsico Lung Institute, University Of North Carolina

The classical view of the airway surface liquid (ASL) of lungs is that it consists of two layers – mucus and periciliary layer (PCL). Mucus layer is propelled by cilia and rides on the top of PCL, which is assumed to be a low viscosity dilute liquid. This model of ASL does not explain what stabilizes the mucus layer and prevents it from penetrating the PCL. I propose a different model of ASL in which PCL consists of a dense brush of mucins attached to cilia. This brush stabilizes mucus layer and prevents it penetration into PCL, while providing lubrication and elastic coupling between beating cilia. Both physical and biological implications of the new model and the remaining puzzles will be discussed.

Tuesday, March 12 at 3:15pm

Regents Hall, 109
3700 O St. NW

Event Type

Academic Events

Audience

Students, Faculty/Staff

Departments

Georgetown College, Physics

Tags

colloquium

Presenter

Prof. Michael Rubinstein, Ph.D., Mechanical Engineering and Materials Science, Biomedical Engineering, Physics, & Chemistry Department, Duke University and Marsico Lung Institute, University Of North Carolina

Event Contact Name

Peter Olmsted

Event Contact Email

pdo7@georgetown.edu

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