Seminar Series: Dr. Beth Roman
BMP signaling in cardiovascular development and disease
Dr. Beth Roman
Department of Human Genetics
Graduate School of Public Health
University of Pittsburgh
Personal Statement: I am trained in toxicology, developmental biology, and genetics and have 19 years’ experience as a vascular developmental biologist. My research has focused primarily on uncovering mechanisms underlying development of arteriovenous malformations (AVMs), in large part using a zebrafish alk1 mutant, which serves as a tool for understanding the human disease, hereditary hemorrhagic telangiectasia (HHT). Combining genetics, molecular biology, embryology, imaging, and bioengineering approaches, we explore the roles of endocrine and paracrine factors as well as biomechanical forces in normal vessel development and AVMs. My research was the first to demonstrate dependence of alk1 expression on blood flow, and our model provides strong support for the idea that AVMs are not genetically determined but in fact represent an adaptive response to altered hemodynamic forces.
This lecture is supported in part by the Dr. Baldev R. Bhussry Memorial Fund.
Tuesday, November 14 at 12:00pm
Basic Science Building, 341
3900 Reservoir Road, N.W., Washington